Phosphorodiamidate Morpholino Oligomers-Loaded Nanobubbles for Ultrasound-Mediated Delivery to the Myocardium in Muscular Dystrophy.

ABSTRACT: Microbubbles (MBs) and nanobubbles (NBs) can oscillate and collapse in response to ultrasound exposure, resulting in contrast and delivery effects. Therefore, the retention of the entrapped gas is an important condition in bubble formulations, especially for MBs and NBs with lipid shells, and the stability of the lipid membrane is considered to be affected. We previously developed NBs, which are polyethylene glycol-modified liposomes entrapping an ultrasound contrast gas that can serve as nucleic acid carriers and ultrasound contrast agents. In particular, NBs containing cationic lipids were useful as systemic delivery tools that can load genes and nucleic acids on their surfaces. However, the gas retention of NBs containing cationic lipids were low, leaving room for improvement as ultraso

SUBMITTER: Endo-Takahashi Y 

PROVIDER: S-EPMC11904648 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature