Safety and Efficacy of Tranexamic Acid in General Surgery.

ABSTRACT:

Importance

Perioperative bleeding is common in general surgery. The POISE-3 (Perioperative Ischemic Evaluation-3) trial demonstrated efficacy of prophylactic tranexamic acid (TXA) compared with placebo in preventing major bleeding without increasing vascular outcomes in noncardiac surgery.

Objective

To determine the safety and efficacy of prophylactic TXA, specifically in general surgery.

Design, setting, and participants

Subgroup analyses were conducted that compared randomized treatment with TXA vs placebo according to whether patients underwent general surgery or nongeneral surgery in the POISE-3 blinded, international, multicenter randomized clinical trial. Participants were 45 years or older, were undergoing noncardiac surgery, had increased cardiovascular risk,

SUBMITTER: Park LJ 

PROVIDER: S-EPMC11904705 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature