Frailty Trajectories Following Adjuvant Chemotherapy and Mortality in Older Women With Breast Cancer.

ABSTRACT:

Importance

Frailty assessed at a single time point is associated with mortality in older women with breast cancer. Little is known about how changes in frailty following cancer treatment initiation affect mortality.

Objective

To evaluate the association between claims-based frailty trajectories following adjuvant chemotherapy initiation and 5-year mortality in older women with stage I to III breast cancer.

Design, setting, and participants

This longitudinal cohort study used the Surveillance, Epidemiology, and End Results cancer registries linked to Medicare claims data (claims from 2003-2019). Women aged 65 years or older with stage I to III breast cancer diagnosed from 2004 to 2017 were included. Eligible women underwent breast surgery followed by adjuvant chemother

SUBMITTER: Duchesneau ED 

PROVIDER: S-EPMC11904708 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature