Polygenic Scores of Cardiometabolic Risk Factors in American Indian Adults.

ABSTRACT:

Importance

Numerous efforts have been made to include diverse populations in genetic studies, but American Indian populations are still severely underrepresented. Polygenic scores derived from genetic data have been proposed in clinical care, but how polygenic scores perform in American Indian individuals and whether they can predict disease risk in this population remains unknown.

Objective

To study the performance of polygenic scores for cardiometabolic risk factors of lipid traits and C-reactive protein in American Indian adults and to determine whether such scores are helpful in clinical prediction for cardiometabolic diseases.

Design, setting, and participants

The Strong Heart Study (SHS) is a large American Indian cohort recruited from 1989 to 1991, with ongoing

SUBMITTER: Sun Q 

PROVIDER: S-EPMC11904716 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature