De-Escalation of Nodal Surgery in Clinically Node-Positive Breast Cancer.

ABSTRACT:

Importance

Increasing evidence supports the oncologic safety of de-escalating axillary surgery for patients with breast cancer after neoadjuvant chemotherapy (NAC).

Objective

To evaluate the oncologic outcomes of de-escalating axillary surgery among patients with clinically node (cN)-positive breast cancer and patients whose disease became cN negative after NAC (ycN negative).

Design, setting, and participants

In the NEOSENTITURK MF-1803 prospective cohort registry trial, patients from 37 centers with cT1-4N1-3M0 disease treated with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) alone or with ypN-negative or ypN-positive disease after NAC were recruited between February 15, 2019, and January 1, 2023, and evaluated.

Exposure

Treatment w

SUBMITTER: Cabioglu N 

PROVIDER: S-EPMC11904723 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature