Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial.

ABSTRACT:

Importance

Fracture-related infection (FRI) is a serious complication following fracture fixation surgery. Current treatment of FRIs entails debridement and 6 weeks of intravenous (IV) antibiotics. Lab data and retrospective clinical studies support use of oral antibiotics, which are less expensive and may have fewer complications than IV antibiotics.

Objective

To evaluate the effectiveness of treatment of FRI with oral vs IV antibiotics.

Design, setting, and participants

The POvIV multicenter, prospective randomized clinical trial was conducted across 24 trauma centers in the US among patients aged 18 to 84 years who had fracture repair or arthrodesis with fixation with implants and developed an FRI without radiographic evidence of osteomyelitis. Patients were enroll

SUBMITTER: Major Extremity Trauma Research Consortium (METRC) 

PROVIDER: S-EPMC11904729 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature