Circulating Blood-Based Proteins in Psychopathology and Cognition: A Mendelian Randomization Study.

ABSTRACT:

Importance

Peripheral (blood-based) biomarkers for psychiatric illness could benefit diagnosis and treatment, but research to date has typically been low throughput, and traditional case-control studies are subject to potential confounds of treatment and other exposures. Large-scale 2-sample mendelian randomization (MR) can examine the potentially causal impact of circulating proteins on neuropsychiatric phenotypes without these confounds.

Objective

To identify circulating proteins associated with risk for schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) as well as cognitive task performance (CTP).

Design, setting, and participants

In a 2-sample MR design, significant proteomic quantitative trait loci were used as candidate instruments,

SUBMITTER: Bhattacharyya U 

PROVIDER: S-EPMC11904806 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature