Role of actin-binding proteins in cataract formation.

ABSTRACT:

Introduction

Actin has been implicated in lens opacification; however, the specific actin-related pathways involved in cataracts remain unelucidated. In this study, actin-related proteome changes and signaling pathways involved in the development of cataracts were evaluated.

Methods

The anterior capsule and phacoemulsification (phaco) cassette contents were collected during cataract surgery from 11 patients with diabetic cataract (DC), 12 patients with age-related cataract (ARC), and seven patients with post-vitrectomy cataract (PVC). Untargeted, global identification and quantification of proteins was performed through liquid chromatography-mass spectrometry with the data-independent acquisition (DIA).

Results

In phaco cassette samples, proteins with significantly lo

SUBMITTER: Karakosta C 

PROVIDER: S-EPMC11904859 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature