Green synthesis of new adamantane-containing dihydropyrimidine derivatives as potential anticancer agents.

ABSTRACT: Despite significant progress in cancer treatment, cancer remains a major focus of research due to medication resistance and side effects. In this study, bioactive adamantane-containing dihydropyrimidine (DHPM) derivatives were synthesized through the multi-component Biginelli reaction of N-(adamant-1-yl)acetoacetamide, benzaldehyde derivatives, and thiourea in the presence of trifluoroacetic acid (TFA, 2 mol%) as catalyst under solvent free conditions. This method provides an effective and significantly improved modification of the original Biginelli reaction in terms of yield and reaction time. The synthesized DHPM derivatives were subjected to cytotoxicity screening against the A-549 human non-small cell lung cancer (NSCLC) cell line to evaluate their effects on cell growth inhibi

SUBMITTER: Moshtaghi Zonouz A 

PROVIDER: S-EPMC11904882 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature