Associations Between Klotho Levels, <i>KL-VS</i> Heterozygosity and Cognition in Schizophrenia.

ABSTRACT:

Background and hypothesis

The relationship between Klotho and cognitive dysfunction in schizophrenia has been scarcely explored, with a few paradoxical findings. Hence, we aimed to enhance our understanding by testing associations between the functional KL-VS gene variant and circulating protein levels.

Research design

This case-control study included 239 healthy controls and 241 patients with schizophrenia, who were comprehensively characterized by neurocognitive tests and further subtyped into cognitive clusters; cognitively deficient (CD) and cognitively spared (CS), using K-means cluster analysis. Linear regression models were run to assess the main and iinteraction effects of the KL-VS heterozygosity (KL-VS^Het+)/KL levels with confounding variables (di

SUBMITTER: Majumdar V 

PROVIDER: S-EPMC11904889 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature