Synthesis of non-canonical amino acids through dehydrogenative tailoring.

ABSTRACT: Amino acids are essential building blocks in biology and chemistry. Whereas nature relies on a small number of amino acid structures, chemists desire access to a vast range of structurally diverse analogues^1-3. The selective modification of amino acid side-chain residues represents an efficient strategy to access non-canonical derivatives of value in chemistry and biology. While semisynthetic methods leveraging the functional groups found in polar and aromatic amino acids have been extensively explored, highly selective and general approaches to transform unactivated C-H bonds in aliphatic amino acids remain less developed^4,5. Here we disclose a stepwise dehydrogenative method to convert aliphatic amino acids into structurally diverse analogues. The key to the success

SUBMITTER: Gu X 

PROVIDER: S-EPMC11904927 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature