Proteomic Analyses of Clots Identify Stroke Etiologies in Patients Undergoing Endovascular Therapy.

ABSTRACT:

Aims

This study aimed to investigate the correlation between clot composition and stroke mechanisms in patients undergoing endovascular therapy (EVT), using proteomic analysis.

Methods

This study included 35 patients with ischemic stroke (cardioembolism [CE], n = 17; large artery atherosclerosis [LAA], n = 6; cancer-related [CR], n = 4; and undetermined (UD) cause, n = 8) who underwent EVT. Retrieved clots were proteomically analyzed to identify differentially expressed proteins associated with the three stroke mechanisms and to develop the machine learning model.

Results

In the discover stage, 3838 proteins were identified using clot samples from 27 patients with CE, LAA, and CR mechanisms. Through functional enrichment and network analysis, 149 proteins were identif

SUBMITTER: Kim TJ 

PROVIDER: S-EPMC11904956 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature