Effects of Graphene Quantum Dots on Renal Fibrosis Through Alleviating Oxidative Stress and Restoring Mitochondrial Membrane Potential.

ABSTRACT: Podocyte injury and proteinuria in glomerular disease are critical indicators of acute kidney injury progression to chronic kidney disease. Renal mitochondrial dysfunction, mediated by intracellular calcium levels and oxidative stress, is a major contributor to podocyte complications. Despite various strategies targeting mitochondria to improve kidney function, effective treatments remain lacking. This study investigates the potential of graphene quantum dots (GQDs) in mitigating renal fibrosis and elucidates their underlying mechanisms. In animal models of Adriamycin-induced nephropathy and 5/6 subtotal nephrectomy, GQDs treatment exhibits anti-inflammatory, anti-fibrotic, and anti-apoptotic effects by restoring podocyte actin structure. These therapeutic benefits are associated with the

SUBMITTER: Kim KH 

PROVIDER: S-EPMC11904958 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature