Functional Connectivity in Chronic Schizophrenia: An EEG Resting-State Study with Corrected Imaginary Phase-Locking.

ABSTRACT: Schizophrenia is a complex disorder characterized by altered brain functional connectivity, detectable during both task and resting state conditions using different neuroimaging methods. To this day, electroencephalography (EEG) studies have reported inconsistent results, showing both hyper- and hypo-connectivity with diverse topographical distributions. Interpretation of these findings is complicated by volume-conduction effects, where local brain activity fluctuations project simultaneously to distant scalp regions (zero-phase lag), inducing spurious inter-electrode correlations.

Aim

In the present study, we explored the network dynamics of schizophrenia using a novel functional connectivity metric-corrected imaginary phase locking value (ciPLV)-which is insensitive to changes in

SUBMITTER: Domingos C 

PROVIDER: S-EPMC11905041 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature