Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First-Episode, Treatment-Naive Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study.

ABSTRACT:

Purpose

Structural changes during depressive episodes in adolescents with major depressive disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed to explore white matter (WM) microstructural changes in first-episode, treatment-naïve adolescents with MDD using an integrated diffusion tensor imaging (DTI) approach.

Method

We recruited 66 subjects, including 37 adolescents with MDD and 29 healthy controls. Two main DTI techniques, automated fiber quantification (AFQ) and tract-based spatial statistics (TBSS), were used to analyze fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) in WM tracts. DTI measures were then correlated with the depressive sympto

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11905106 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature