Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility.

ABSTRACT: Rationale: Neurons producing Gonadotropin-Releasing Hormone (GnRH) are essential for human reproduction and have to migrate from nose to brain during prenatal life. Impaired GnRH neuron biology results in alterations of the reproductive axis, including delayed puberty and infertility, with considerable effects on quality of life and metabolic health. Although various genes have been implicated, the molecular causes of these conditions remain elusive, with most patients lacking a genetic diagnosis. Methods: GnRH neurons and non-GnRH cells were FACS-isolated from mouse embryo microdissections to perform high-resolution transcriptomic profiling during mouse embryonic development. We analyzed our dataset to reveal GnRH neuron molecular identity, gene expression dynamics, and cell

SUBMITTER: Zouaghi Y 

PROVIDER: S-EPMC11905127 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature