Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment.

ABSTRACT: Rationale: The utilization of dissolving microneedles (MNs) facilitates the painless delivery of pharmaceuticals via the transdermal route. However, conventional MNs rely on passive diffusion through the gradual dissolving of the matrix, which can impede the therapeutic efficacy of the delivered drugs. Methods: In this study, we present the development of a novel degradable active MNs platform. This platform employs sodium bicarbonate and citric acid loaded in a dissolving MNs patch as a built-in motor for deeper and faster intradermal payload delivery. The sodium bicarbonate microparticles and citric acid undergo a chemical reaction when in contact with tissue fluid, resulting in the rapid formation of explosive carbon dioxide bubbles. This provides the necessary forc

SUBMITTER: Liu T 

PROVIDER: S-EPMC11905133 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature