Sex- and age-specific sensitivities of the endocannabinoid system in Alzheimer's disease revealed by PET imaging with [¹⁸F]FMPEP-<i>d</i> ₂ and [¹⁸F]MAGL-2102.

ABSTRACT: The endocannabinoid system is a critical brain signaling pathway that is dysregulated in various brain disorders, including Alzheimer's disease (AD). Cannabinoid-targeted therapies and imaging approaches have gained increasing interest; however, the biological impact of the endocannabinoid system in disease needs further validation. We aimed to study changes in cannabinoid receptor 1 (CB1) and monoacylglycerol lipase (MAGL), components of endocannabinoid signaling and degradation, in a mouse model of AD by PET imaging. Methods: [¹⁸F]FMPEP-d ₂ and [¹⁸F]MAGL-2102 were produced on a commercial radiosynthesis module. PET-CT images with both tracers were acquired in a knock-in mouse model of AD bearing mutated human amyloid precursor protein (Ap

SUBMITTER: Pees A 

PROVIDER: S-EPMC11905134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature