Investigating the molecular mechanism of purslane‑based vitiligo treatment using network pharmacology, molecular docking and <i>in vitro</i> analyses.

ABSTRACT: Purslane is a traditional Chinese medicine with a long‑standing history of efficacy in the management of dermatological conditions such as vitiligo. However, the molecular mechanisms underlying its therapeutic effects on vitiligo remain unclear. Therefore, the present study explored these mechanisms using network pharmacology, molecular docking and in vitro experiments. Following the screening process, seven principal active components were identified, namely kaempferol, hesperetin, luteolin, quercetin, arachidonic acid, cycloartenol and β‑sitosterol. In addition, six key targets, namely AKT1, tumor protein p53, peroxisome proliferator‑activated receptor γ (PPARG), estrogen receptor 1, prostaglandin‑endoperoxidase synthase 2 and mitogen‑activated protein kinase 1, and eight pathways

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11905198 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature