Enhancing targeted doses: Low-energy photon lipiodol-enhanced radiotherapy (LEPERT) for liver cancer patients.

ABSTRACT:

Objectives

This study proposes a novel approach, "Low-energy photon Lipiodol-Enhanced Radiotherapy" (LEPERT), for patients with liver cancer. Moreover, we evaluate the dose difference of the conventional treatment planning with 10 MV X-ray beam (MV-plan) and LEPERT.

Methods

The computed tomography (CT) was modeled with the Monte Carlo simulation. For LEPERT, 120 kV X-ray beams collimated with CT were irradiated on a virtual tumor filled with Lipiodol at 10-50 mg/mL, which was inserted into a whole-body phantom. A prescribed dose of 40 Gy/4fr was irradiated to achieve D_95% of the target. The doses to the target and organs at risk (OARs), such as the bone, normal liver, spinal cord, and kidneys, were evaluated by comparison with conventional radiotherapy with a 10 M

SUBMITTER: Kawahara D 

PROVIDER: S-EPMC11905249 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature