Arterial spin labelling perfusion MRI analysis for the Human Connectome Project Lifespan Ageing and Development studies.

ABSTRACT: The Human Connectome Project Lifespan studies cover the Development (5-21) and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in the imaging protocol, resulting in one of the largest datasets collected to-date of high spatial resolution multiple delay ASL covering 3,000 subjects. The HCP-ASL minimal processing pipeline was developed specifically for this dataset to pre-process the image data and produce perfusion estimates in both volumetric and surface template space, though quality control is not performed. Applied to the whole dataset, the outputs of the pipeline revealed significant and expected differences in perfusion between the Development and Ageing cohorts. Visual inspection of the group average surface maps showed that cortical perfusion often followe

SUBMITTER: Kirk TF 

PROVIDER: S-EPMC11905292 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature