Whole genome analysis revealed the role of <i>bla</i>_OXA-23 and <i>bla</i>_OXA-66 genes in carbapenem resistance of <i>Acinetobacter baumannii</i> strains.

ABSTRACT: Acinetobacter baumannii is a multidrug-resistant bacterium that has emerged as a significant nosocomial pathogen globally and renowned for its ability to acquire antimicrobial resistance (AMR) genes. However, understanding of its resistance mechanisms to certain drug classes remains limited. This study focused on four bacterial strains (AB863, AB889, AB930, and AB960) exhibiting carbapenem resistance. They demonstrated high minimum inhibitory concentration (MIC) (128 mg/L) to meropenem and were categorized as extensively drug-resistant strains. Subsequently, they were identified as A. baumannii through 16S rRNA gene sequence analysis and species-specific PCR targeting the bla_OXA51-like gene. Three strains were sequenced for their genomes to study the genetic

SUBMITTER: Mat Ghani N 

PROVIDER: S-EPMC11905307 | biostudies-literature | 2025 Feb-Mar

REPOSITORIES: biostudies-literature