Investigating the role of eight SNPs in <i>CHRNA3</i> for COPD susceptibility in the Chinese elderly population.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with CHRNA3 emerging as a promising candidate gene due to its involvement in smoking behavior and lung function. This study aimed to investigate the association between eight CHRNA3 SNPs and COPD susceptibility in the Chinese elderly population.

Methods

A total of 270 COPD patients and 271 healthy controls were included in the study. SNP genotyping was carried out using the Agena MassARRAY platform. Logistic regression analysis was employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between the SNPs and COPD risk. Forest plot

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11905312 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature