System Analysis Identifies MYBL2 As a Novel Oncogene Target for Metastatic Prostate Cancer.

ABSTRACT: Bone metastasis significantly contributes to the unfavorable prognosis observed in patients with prostate cancer. MYB proto-oncogene like 2 (MYBL2) has been identified as a potential target gene implicated in tumor progression. Nevertheless, the oncogenic role and underlying mechanisms of MYBL2 in bone metastasis of prostate cancer (PCa) have yet to be elucidated. Bioinformatics analyses were employed to identify genes pivotal to metastatic PCa. Subsequently, a series of molecular biology experiments in vitro, alongside a model of PCa bone metastasis in vivo, were utilized to validate the pro-metastatic effects and underlying mechanisms of MYBL2. A bioinformatics analysis identified a candidate set of 72 genes, which was used to establish a PFS prognostic model highlighting 16 key genes. B

SUBMITTER: Huang R 

PROVIDER: S-EPMC11905402 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature