Clinical significance and immune landscape analyses of the coagulation-related gene signatures in gastric cancer.

ABSTRACT: Gastric cancer (GC) is one of the most common types of clinically malignant tumors and a global health challenge due to its high mortality and poor prognosis. The coagulation cascade is closely related to GC and plays a key role in the tumor immune microenvironment. However, the specific mechanisms by which coagulation-related genes involved in the occurrence and development of GC remains unclear. The data of GC patients and coagulation-related genes were obtained from the TCGA and the GSEA databases, respectively. After univariate Cox regression analysis, the non-negative matrix factorization method was used to identify coagulation-related molecular subtypes. GC patients were categorized into high-risk and low-risk score groups based on median risk scores, which included six genes (PCDHAC

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11905418 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature