Fecal microbiota transplantation mitigates postdieting weight regain in mice by modulating the gut-liver axis.

ABSTRACT:

Background

Dysbiosis of the microbiome is strongly associated with weight rebound after dieting. However, the interactions between the host and microbiome and their relevance to the pathogenesis of post-diet weight rebound remain unclear.

Purpose

This study aimed to evaluate the effects of fecal microbiota transplantation (FMT) on post-diet weight regain and to investigate the underlying mechanisms by which FMT inhibits weight regain.

Methods

FMT was administered once daily to mice for 5 weeks. Gas chromatography tandem mass spectrometry was employed to analyze short-chain fatty acid levels in serum, ultrahigh-performance liquid chromatography tandem mass spectrometry was utilized for analyzing hepatic lipid metabolites, and shotgun metagenomic sequencing was applied

SUBMITTER: Cao H 

PROVIDER: S-EPMC11905490 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature