Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse.

ABSTRACT:

Background

Gelsemium elegans (G. elegans) is widely recognized as one of the most toxic plants globally, particularly harmful to humans. Some reports indicate that it is non-toxic to pigs and even has a growth-promoting effect; however, the underlying reasons for this paradox remain unclear.

Methods

Gelsenicine is the main toxic component of G. elegans. This study characterized gelsenicine-induced toxicity using electrophysiological recordings, molecular dynamic simulations, c-Fos immunostaining, and multi-omics technologies. Additionally, we conducted a comprehensive analysis comparing the toxic effects of gelsenicine across various animal species through examinations of tissue distribution, blood gas analysis, metabonomics, and behavioral tests.

Results

We demonstra

SUBMITTER: Huang CY 

PROVIDER: S-EPMC11905507 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature