Total bilirubin as a marker for hemolysis and outcome in patients with severe ARDS treated with veno-venous ECMO.

ABSTRACT:

Background

Hemolysis is a common complication in critically ill patients with sepsis, acute respiratory distress syndrome (ARDS) or therapy with extracorporeal membrane oxygenation (ECMO). Heme degradation product bilirubin might accumulate in conditions of significant hemolysis. In patients with ARDS and therapy with veno-venous ECMO (vvECMO), the prognostic potential of elevated initial total bilirubin (tBili) was investigated.

Methods

Retrospective analysis of patients with ARDS and vvECMO-therapy (n = 327) admitted to a tertiary ARDS center. A tBili cut-off value was determined by binary recursive partitioning. Baseline characteristics were compared and relevant variables were included in a multivariate logistic regression model with backward variable selection. Primary

SUBMITTER: Bunger V 

PROVIDER: S-EPMC11905513 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature