Change in diffusion weighted imaging after induction chemotherapy outperforms RECIST guideline for long-term outcome prediction in advanced nasopharyngeal carcinoma.

ABSTRACT:

Purpose

To investigate change in diffusion weighted imaging (DWI) between pre-treatment (pre-) and after induction chemotherapy (post-IC) for long-term outcome prediction in advanced nasopharyngeal carcinoma (adNPC).

Materials and methods

Mean apparent diffusion coefficients (ADCs) of two DWIs (ADC_pre and ADC_post-IC) and changes in ADC between two scans (ΔADC%) were calculated from 64 eligible patients with adNPC and correlated with disease free survival (DFS), locoregional recurrence free survival (LRRFS), distant metastases free survival (DMFS), and overall survival (OS) using Cox regression analysis. C-indexes of the independent parameters for outcome were compared with that of RECIST response groups. Survival rates between two patient groups were ev

SUBMITTER: Ai QYH 

PROVIDER: S-EPMC11905565 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature