Prognostic role of STMN1 expression and neoadjuvant therapy efficacy in breast cancer.

ABSTRACT:

Purpose

breast cancer is common and highly malignant, currently, STMN1 was found to be associated with several human malignancies. The purpose of this study is to investigate STMN1 expression in breast cancer and explore its role in disease progression and its interaction with neoadjuvant therapy efficacy.

Methods

we analyzed the tissue STMN1 mRNA expression in BC tissue samples from 105 patients received with neoadjuvant therapy using qPCR between 2019 and 2022.

Results

Statistical analysis showed that a high expression of STMN1 before neoadjuvant chemotherapy (NACT) was a trend positively related to non-pCR in the ITT (Intention to Treat) population, while in patients with paclitaxel or docetaxel regimens, before-NACT STMN1 expression was obviously higher in non-pCR

SUBMITTER: Qian L 

PROVIDER: S-EPMC11905611 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature