Bradykinin's carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction.

ABSTRACT:

Background

Uremic impairment of wound healing is a well-established phenomenon, however the etiology of this condition continues to be a medical enigma. Carbamylation, posttranslational modification (PTM) occurring with high frequency in uremic milieu, is known to have impact on structural and functional properties of proteins and peptides. Herein we show that carbamylation of the members of kinin-kallikrein system, that play an essential role in wound healing process, results in its aberrant functionality and impedes the complex process of tissue regeneration in uremic patients.

Results

Through enzymatic assays we demonstrate that carbamylation of kininogen results in aberrant bradykinin generation. We confirmed that bradykinin is efficiently carbamylated in uremic conditio

SUBMITTER: Kaminska M 

PROVIDER: S-EPMC11905624 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature