Centripetal migration and prolonged retention of microglia promotes spinal cord injury repair.

ABSTRACT:

Background

Recent studies have confirmed the critical role of neonatal microglia in wound healing and axonal regeneration following spinal cord injury (SCI). However, the limited migration of microglia to the center of adult lesion may significantly impede their potential benefits.

Methods

We established a model of microglial centripetal migration and prolonged retention in C57BL/6J and transgenic mice by injecting exogenous C-X3-C motif chemokine ligand 1 (CX3CL1) and macrophage colony-stimulating factor (M-CSF) directly into the lesion site post-SCI. Wound healing and axonal preservation/regrowth was assessed anatomically, and kinematics analysis was conducted to determine the recovery of locomotor function.

Results

We identified decreased expression and perilesiona

SUBMITTER: Ye J 

PROVIDER: S-EPMC11905688 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature