Transcriptomic and proteomic analyses of sclera in lens-induced myopic guinea pigs.

ABSTRACT:

Background

Myopia development is commonly assessed by an increase in axial length, which may lead to high myopia and visual impairment. This study aims to identify potential biomarkers and signaling pathways in the sclera during experimental axial elongation.

Methods

A myopia guinea pig model was established using male guinea pigs aged 2-3 weeks, which underwent bilateral lens-induced myopization (LIM) (study group) or were left untreated (control group). An integrated analysis of transcriptomic and proteomic was performed to identify differentially expressed genes (DEGs) in the sclera. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to explore the DEGs related signaling pathways. Promising candidate markers were further tested b

SUBMITTER: Li HY 

PROVIDER: S-EPMC11905693 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature