Natriuretic peptide levels and predicting risk of developing new diabetes mellitus and metabolic syndrome.

ABSTRACT:

Aims

Define the relationship between N-terminal atrial natriuretic peptide (NT-ANP) levels and incident metabolic syndrome and type 2 diabetes mellitus ('metabolic disease') in healthy adults and develop a risk prediction score.

Materials and methods

Retrospective cohort study of Olmsted County Heart Function Study participants, a random sampling of county residents aged 45 years and older (n = 2042). Clinical data were collected during enrolment between 1997 and 2000 and upon follow-up 4 years later. Outcomes were followed for 8 years. We studied 715 subjects without metabolic disease at enrolment who completed follow-up, assessing incident metabolic disease as the primary outcome. Youden's index was used to identify optimal cut-points and develop the risk score.

Results

SUBMITTER: Singh J 

PROVIDER: S-EPMC11905735 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature