Lipid-lowering therapies for aortic stenosis: a drug-target Mendelian randomization study.

ABSTRACT:

Introduction

Large observational and Mendelian randomization (MR) studies have demonstrated a strong association between both elevated LDL cholesterol (LDL-c) and triglycerides (TG) with risk of aortic stenosis (AS), although randomized trials showed no benefit of statins for AS. It consequently remains uncertain whether lipid-lowering therapies have a role to prevent or treat AS. We used a drug-target MR approach to investigate the genetically predicted effect of lipid-lowering therapies on risk of AS.

Methods and results

We collected summary statistics for LDL-c, TG, and AS from genome-wide association studies (GWAS) including 1 320 016, 1 253 277, and 412 181 European participants from the Global Lipids Genetics Consortium and FinnGen study, respectively. We identified ge

SUBMITTER: Ciofani JL 

PROVIDER: S-EPMC11905763 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature