The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis.

ABSTRACT:

Background

This systematic review and meta-analysis aimed to examine the performance of polymerase chain reaction (PCR) assays for diagnosing mucormycosis.

Methods

A standardised search was conducted from conception to December 3rd 2024 using PubMed, Embase, Global Health, and Cochrane library. Original studies that used PCR-based methods on any human specimen to diagnose mucormycosis were analysed for eligibility. Using a bivariate meta-analysis, the diagnostic performance of PCR was examined against the European Organisation for Research and Treatment of Cancer-Mycoses Study Group Education and Research Consortium 2020 (EORTC-MSGERC) definitions of proven and probable invasive mould disease, which was modified to include all patients at risk of mucormycosis. The study prot

SUBMITTER: Brown L 

PROVIDER: S-EPMC11905852 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature