Epigenetic Modifications Associated With Wildland-Urban Interface (WUI) Firefighting.

ABSTRACT: Wildland-urban interface (WUI) firefighting involves exposure to burning vegetation, structures, and other human-made hazards, often without respiratory protection. Response activities can last for long periods of time, spanning multiple days or weeks. Epigenetic modifications, including microRNA (miRNA) expression and DNA methylation, are responsive to toxicant exposures and are part of the development of cancers and other diseases. Epigenetic modifications have not been studied in relation to WUI fires. Firefighters (n = 99) from southern California, including 79 firefighters who responded to at least one WUI fire, provided blood samples at baseline and approximately 10 months later. We quantified the relative abundance of 800 miRNAs in blood samples using the nCounter Human v3 miRNA exp

SUBMITTER: Goodrich JM 

PROVIDER: S-EPMC11905879 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature