A new nomogram for predicting 90-day outcomes of intravenous thrombolysis in patients with acute ischaemic stroke.

ABSTRACT:

Background

The aim of this study was to construct and validate a new nomogram to predict the risk of poor outcome in patients with acute ischemic stroke (AIS) after intravenous thrombolytic therapy (IVT).

Methods

A total of 425 patients who received IVT within 4.5 h of stroke onset were included in a retrospective study. All the patients were divided into training (70%, n = 298) and validation cohorts (30%, n = 127). Poor outcome (defined as a 90-day modified Rankin Scale score 3-5) was the primary outcome. Logistic regression was used for analysis of independent risk factors for poor outcome in patients with AIS. Nomograms of poor outcome in AIS patients were constructed using R software. Discrimination and calibration of the models were assessed using area un

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11905897 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature