The Association Between Neuropathological Lesions and Body Mass Index Is Independent of Cognitive Abilities.

ABSTRACT:

Background

The association of moderate and severe dementia with low body mass index (BMI) is well described, but weight decline seems to also occur in individuals with preclinical neuropathologies. Considering that up to one-fifth of individuals with normal cognition meet the criteria for a dementia-related neuropathological diagnosis, autopsy studies are key to detecting preclinical neurodegenerative and cerebrovascular diseases that could be underlying weight changes.

Objective

We investigated the association between dementia-related brain lesions and BMI and evaluated whether the cognitive function was a mediator of this association.

Methods

In 1,170 participants, sociodemographic data, clinical history, and cognitive post-mortem evaluation were assessed with an in

SUBMITTER: Ururahy RDR 

PROVIDER: S-EPMC11905978 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature