The memory binding test in a longitudinal study of cognitive aging and preclinical disease.

ABSTRACT:

Objective

The Memory Binding Test (MBT) shows promise in detecting early cognitive changes associated with Alzheimer's disease (AD). This study assesses the psychometric properties (i.e., construct and criterion validity, test-retest reliability) of the MBT and its sensitivity to incipient disease and incident cognitive impairment.

Method

One hundred forty-nine cognitively unimpaired adults ages 45-85 completed the MBT and neuropsychological tests at baseline; 132 returned for 2-year follow-up. Based on neuroradiological ratings of amyloid positron emission tomography and MRI markers at baseline, they were categorized as healthy (n = 94) or having preclinical disease (n = 55, either on the AD continuum or having non-AD pathologic change). Construct validity was

SUBMITTER: Aghamoosa S 

PROVIDER: S-EPMC11905987 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature