Non-sputum-based triage and confirmatory diagnostic tests for pediatric TB.

ABSTRACT:

Background

Non-sputum-based triage and confirmatory tests are essential for early TB detection and timely treatment in children.

Methods

A mini-review was conducted from January 2022 to May 2024, evaluating five studies on non-sputum-based assays for childhood TB diagnosis. Both Microbiological and Clinical Reference Standards were used to assess diagnostic accuracy and triage potential.

Results

Among the confirmatory tests, only the gastric aspiration test with cartridge-based nucleic acid amplification tests (CBNAAT) met the WHO Target Product Profile criteria. However, this method remains invasive and is not suitable for point-of-care testing. Urine testing by gas chromatography-mass spectrometry (GC/MS) or C-ELISA (BJ76/A194) demonstrated high performance but lack

SUBMITTER: Drane A 

PROVIDER: S-EPMC11906028 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature