Long-term outcomes of LT4/LT3 combination treatment for persistent hypothyroid symptoms.

ABSTRACT:

Objective

Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the patient group experiencing a long-lasting impact of LT4/LT3 and evaluate their quality of life (QoL) and hypothyroid symptoms.

Method

We performed a cross-sectional study of 66 hypothyroid patients who had previously initiated LT4/LT3 combination therapy. The patients were grouped by current treatment into patients still receiving LT4/LT3 treatment (T3 responders) and patients who had discontinued LT3 treatment due to lack of effect (T3 non-responders). ThyPRO was used to evaluate QoL, and a validated symptom score was used to assess hypoth

SUBMITTER: Nygaard B 

PROVIDER: S-EPMC11906148 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature