Estimating per-infection cost and burden for dengue and Zika as a function of antibody-dependent enhancement.

ABSTRACT: The complex immune interactions produced by the tetravalent dengue vaccine Dengvaxia have foregrounded the important role of antibody-dependent enhancement (ADE) in dengue infection. Some evidence exists that ADE may extend beyond the four dengue serotypes to Zika, a closely related flavivirus transmitted by the same mosquito species as dengue, and may also account for the increased severity of some cases. Estimates of the public health impact of dengue vaccination may then need to include its effects on the transmission of Zika in addition to dengue. This study gathers primary references to build estimates of per-case economic cost and disease burden for dengue and Zika infection with and without ADE in the ten countries where clinical trials were held for Dengvaxia, under the hypothesis

SUBMITTER: Kribs CM 

PROVIDER: S-EPMC11906165 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature