Skin-compatible Carbopol^® Electrospun Fiber Membranes with pH-Dependent Rheological Properties for Biomedical Applications.

ABSTRACT: Properties of pH-responsive electrospun nanofibers incorporated with biocompatible/degradable Carbopol^®, commonly used in pharmaceuticals and personal care products, are reported. Sonication of Carbopol^® dispersions prior to electrospinning leads to uniform incorporation into fibers of the host polymer polyvinylpyrrolidone. The hydration behavior is strongly influenced by pH conditions, forming a viscous network at higher pH. Since Carbopol^® is more responsive to higher pH, at pH > 6 increasing Carbopol^® concentration leads to increased uptake volume of buffer solution, faster uptake rate and complete gel formation. The physical spreadability (resulting from a combination of viscoelastic properties and the structural polymer network) of the hydra

SUBMITTER: Han D 

PROVIDER: S-EPMC11906188 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature