A comprehensive prognostic and immune analysis of <i>LAPTM4B</i> in pan-cancer and Philadelphia chromosome-positive acute lymphoblastic leukemia.

ABSTRACT:

Introduction

Lysosomal-associated protein transmembrane-4 beta (LAPTM4B) protein expression was increased in solid tumors, whereas few studies were performed in hematologic malignancies. We aimed to study the effect of the LAPTM4B gene in pan-cancer and Philadelphia chromosome-positive acute B cell lymphoblastic leukemia (Ph+ B-ALL).

Methods

The differential expression, diagnosis, prognosis, genetic and epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell analysis, and drug response across cancers were conducted based on multiple computational tools. Additionally, Ph+ B-ALL transgenic mouse model with Laptm4b knockout was used to analyze the function of LAPTM4B in vivo. BrdU incorporation method, flow cy

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11906416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature