Identification of subgroups of early-stage mycosis fungoides patients with increased itch and impaired quality of life.

ABSTRACT:

Introduction

Mycosis fungoides (MF), Sézary syndrome (SS) and other cutaneous T-cell lymphomas (CTCLs) can have a severe impact on quality of life (QoL) and itch, but early MF is insufficiently investigated despite representing most patients. This single center study investigated associations between QoL/itch/depressive symptoms and clinical phenotypes in patients with CTCL with particular focus on early MF-stages.

Methods

Patients were included during routine dermatological care. The primary outcomes included Dermatology Life Quality Index (DLQI), EuroQoL 5D (EQ-5D) index, Montgomery-Åsberg Depression Rating Scale - Self report (MADRS-S), and itch measured with a visual analogue scale (VAS-itch).

Results

In the total CTCL cohort (n=76), median EQ-5D index was impaire

SUBMITTER: Nenonen J 

PROVIDER: S-EPMC11906425 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature