Inflammation-fibrosis interplay in inflammatory bowel disease: mechanisms, progression, and therapeutic strategies.

ABSTRACT:

Background

The incidence of intestinal fibrosis in Inflammatory bowel disease has increased in recent years, and the repair process is complex, leading to substantial economic and social burdens. Therefore, understanding the pathogenesis of intestinal fibrosis and exploring potential therapeutic agents is crucial.

Purpose

This article reviews the pathogenesis of IBD-related intestinal fibrosis, potential therapeutic targets, and the progress of research on Traditional Chinese Medicine (TCM) in inhibiting intestinal fibrosis. It also provides foundational data for developing innovative drugs to prevent intestinal fibrosis.

Methods

This article reviews the literature from the past decade on advancements in the cellular and molecular mechanisms underlying intestinal fibr

SUBMITTER: Li Y 

PROVIDER: S-EPMC11906429 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature