Serum-derived exosomal microRNAs as biomarkers for postoperative delirium.

ABSTRACT:

Introduction

Postoperative delirium (POD) is a frequent and challenging complication in elderly surgical patients, marked by abrupt cognitive and attentional disturbances. Current POD diagnosis depends on clinical assessments that are time-intensive and lack predictive accuracy before surgery. Although previous research has explored biomarkers such as neuroinflammatory factors and Alzheimer's-related proteins to enhance POD prediction, single molecular markers have proven insufficient for reliable prognosis.

Methods

This study investigated serum exosomal miRNA expression profiles in postoperative patients to assess their association with POD. We compared miRNA expression between POD and non-POD groups through cognitive assessments and serum analyses. Additionally, enrichment

SUBMITTER: Xu M 

PROVIDER: S-EPMC11906430 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature