Unveiling the immunological landscape of disseminated tuberculosis: a single-cell transcriptome perspective.

ABSTRACT:

Introduction

Hematogenous disseminated tuberculosis (DTB) has an unclear etiology that likely involves multiple factors. Understanding the underlying immunological characteristics of DTB is crucial for elucidating its pathogenesis.

Methods

We conducted single-cell RNA transcriptome and T cell receptor (TCR) sequencing on samples from seven DTB patients. Additionally, we integrated and analyzed data from two published profiles of latent TB infection, three active TB cases, and two healthy controls.

Results

Our analysis revealed a significantly higher proportion of inflammatory immune cells (e.g., monocytes and macrophages) in DTB patients, along with a notably lower abundance of various lymphocytes (including T cells, B cells, and plasma cells), suggesting that lymphop

SUBMITTER: Gong Z 

PROVIDER: S-EPMC11906432 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature