Modulation and distribution of extracellular free water and tract deficits in rhesus macaques before and after the initiation of emtricitabine + tenofovir disoproxil fumarate + dotutegravir treatment.

ABSTRACT:

Introduction

Understanding the specific timing of cART initiation, its effectiveness, and failures, as well as assessing how well the current cART regimens control viral replication and rebound, enhance immune function, and repair or curb early injury in the central nervous system (CNS), is crucial to improving the livelihood of people living with HIV.

Methods

Here, we use an animal model to provide controlled environments to understand how the bodies of Chinese-origin rhesus monkeys, both the immune system and CNS, respond to a combination of emtricitabine (EMTBL/FTC), dolutegravir (DTG), and tenofovir disoproxil fumarate (TDF) following the induction of Simian Immunodeficiency Virus (SIV). We injected the rhesus monkeys with a dose

SUBMITTER: Nguchu BA 

PROVIDER: S-EPMC11906442 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature